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Cardio-Renal Syndrome Type 4: The Correlation Between Cardiorenal Ultrasound Parameters

Silvia Lai1, Mauro Ciccariello, Mira Dimko

  • 1Department of Clinical Medicine, Sapienza University of Rome, Rome, Italy.

Kidney & Blood Pressure Research
|September 26, 2016
PubMed

Insights

Chronic kidney disease (CKD) patients show impaired right ventricle function. Renal resistive index and echocardiographic parameters can help diagnose cardiorenal syndrome in CKD.

Area of Science:

  • Nephrology
  • Cardiology
  • Cardiorenal Medicine

Background:

  • Cardiovascular diseases are a leading cause of death in chronic kidney disease (CKD) patients.
  • Cardiorenal syndrome type 4 describes the interaction between heart and kidney in CKD.
  • Early identification of cardiovascular risk markers in CKD is crucial.

Purpose of the Study:

  • To assess the association between renal and cardiovascular ultrasonographic parameters in CKD patients.
  • To identify early markers of cardiovascular risk in the context of cardiorenal syndrome.
  • To evaluate differences in inflammatory and mineral metabolism indexes between CKD patients and controls.

Main Methods:

  • Enrolled 35 CKD patients and 25 healthy controls.
  • Evaluated inflammatory indexes, mineral metabolism, and renal function.
  • Assessed renal and cardiovascular ultrasonographic parameters, including Tricuspid anular plane systolic excursion (TAPSE) and estimated pulmonary artery systolic pressure (ePAPs).

Main Results:

  • Significant differences observed in TAPSE, ePAPs, 25-hydroxyvitaminD (25-OH-VitD), parathyroid hormone (iPTH), phosphorus, serum uric acid, renal resistive index (RRI), and C-reactive protein (CRP) between groups.
  • TAPSE correlated positively with estimated glomerular filtration rate (eGFR) and negatively with RRI.
  • ePAPs correlated negatively with eGFR and positively with RRI.

Conclusions:

  • CKD contributes to right ventricle dysfunction, endothelial dysfunction, inflammation, and mineral metabolism disorders.
  • Right ventricle function assessment is recommended for CKD patients.
  • RRI and echocardiographic parameters are valuable tools for diagnosing and managing cardiorenal syndrome in CKD.

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