Coronary artery dominance dependent collateral development in the human heart
N O Ajayi, E A Vanker, K S Satyapal1
1Department of Clinical Anatomy, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, South Africa, South Africa. satyapalk@ukzn.ac.za.
Folia Morphologica
|September 27, 2016
Summary
Coronary collateral artery development is influenced by coronary artery morphology, particularly a right dominant pattern, but not by patient age or sex. This natural bypass improves blood flow in obstructive coronary artery disease.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Anatomy
Background:
- Coronary collateral arteries act as natural bypasses in obstructive coronary artery disease.
- They reroute blood flow to ischemic myocardial tissue.
Purpose of the Study:
- To investigate demographic and morphologic factors influencing coronary collateral development.
- To understand the role of coronary artery anatomy in collateralization.
Main Methods:
- Analysis of coronary angiograms from 286 patients with total coronary artery obstruction.
- Collateral flow graded (0-3) based on donor-recipient artery connections.
Main Results:
- No significant association found between patient age/sex and excellent collateral formation.
- Atherosclerotic lesion location impacted collateral development in the right coronary artery.
- A right coronary artery dominant pattern significantly enhanced collateral development.
Conclusions:
- Coronary arterial morphology, specifically a right dominant pattern, positively influences coronary collateral artery development.
- These findings highlight the anatomical basis of natural coronary bypasses.
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