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microRNAs involved in Parkinson's disease: A systematic review
Franciele Cascaes da Silva1, Rodrigo da Rosa Iop1, Giovanna Grunewald Vietta1
1Department of Physical Education, Center for Health Sciences and Sports, Adapted Physical Activity Laboratory, University of State of Santa Catarina, Florianopolis 88080‑350, Brazil.
Abstract:
The aim of the present study was to determine the expression of blood microRNAs (miRNAs) involved in PD in humans. For this purpose the following electronic databases were selected: MEDLINE by Pubmed, Scopus and Web of Science. The search strategy included the proposed descriptors in the Medical Subject Headings. There were no restrictions with respect to the language of the publication. In the study selection two independent reviewers initially evaluated studies that were identified by the search strategy according to titles and abstracts. The reviewers evaluated (also unassisted) the complete articles and selected studies according to the eligibility criteria specified above. Studies that were not in accordance with the adopted criteria were excluded according to the boundaries imposed by the search strategy. The following data were extracted from the selected studies: Publication identification, location where the study was conducted, study design, the sample size, the participants' characteristics, the miRNAs involved in PD, the miRNA detection and analysis method, and the type of miRNA dysregulation in PD. Through this systematic review of the literature published over the last 10 years, the expression of 91 different miRNAs were analyzed in the context of PD, with the expression of 39 of these miRNAs differing significantly between individuals with PD and healthy controls and/or between treated and untreated patients with PD. The miRNAs were extracted from mononuclear cells, leukocytes, plasma, serum and peripheral blood, and the majority of the studies used reverse transcription‑quantitative polymerase chain reaction (RT-qPCR), which is considered to be the gold standard for miRNA analysis.
Insights
This study analyzed blood microRNAs (miRNAs) in Parkinson's Disease (PD). 39 out of 91 investigated miRNAs showed significant expression differences in PD patients, highlighting their potential as biomarkers.
Area of Science:
- Biochemistry
- Genetics
- Neurology
Background:
- Parkinson's Disease (PD) is a neurodegenerative disorder with complex etiology.
- MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression and are implicated in various diseases, including PD.
- Identifying reliable biomarkers for early diagnosis and monitoring of PD is crucial.
Purpose of the Study:
- To systematically review and analyze the expression of blood microRNAs (miRNAs) associated with Parkinson's Disease (PD) in humans.
- To identify specific miRNAs that are differentially expressed in individuals with PD compared to healthy controls or between treated and untreated patients.
Main Methods:
- A systematic literature review was conducted using databases like MEDLINE, Scopus, and Web of Science.
- Studies published within the last 10 years were screened by two independent reviewers based on titles, abstracts, and full articles.
- Data extraction included study characteristics, involved miRNAs, detection methods (primarily RT-qPCR), and miRNA dysregulation patterns in PD.
Main Results:
- Analysis encompassed the expression of 91 different miRNAs in the context of PD.
- Significant differences in expression were observed for 39 miRNAs between PD patients and healthy controls, and/or between treated and untreated PD patients.
- MiRNAs were extracted from various blood components, including mononuclear cells, leukocytes, plasma, and serum.
Conclusions:
- Blood-based miRNA expression profiles offer potential as biomarkers for Parkinson's Disease.
- The significant dysregulation of specific miRNAs in PD patients warrants further investigation for diagnostic and therapeutic applications.
- Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) remains the gold standard for miRNA analysis in these studies.
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