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Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats.
Daniel Fernando Pereira Vasconcelos1, Felipe Rodolfo Pereira da Silva1, Moara E Silva Conceição Pinto1
1Department of Biomedicine, Laboratory of Histological Analysis and Preparation, Federal University of Piaui, Parnaiba, Brazil.
Journal of Periodontology
|September 27, 2016
Summary
Induced periodontitis in rats caused liver damage, including steatosis and reduced pericytes. This suggests a link between gum disease and liver health, highlighting increased oxidative stress and lipid peroxidation.
Area of Science:
- Periodontology
- Hepatology
- Pathology
Background:
- Periodontitis, a gum disease, is linked to systemic conditions like rheumatoid arthritis, diabetes, and liver disease.
- The study investigates how periodontitis impacts liver health through its systemic effects.
Purpose of the Study:
- To explore the association between induced periodontitis and liver damage.
- To understand the systemic consequences of periodontitis on hepatic tissues.
Main Methods:
- Twenty rats were divided into control and periodontitis groups.
- Evaluated periodontal parameters (GBI, PD, MPO, ABL), liver histology, NG2+ pericytes, GSH, MDA, and liver enzymes (AST, ALT).
Main Results:
- Periodontitis was confirmed by increased GBI, PD, MPO, and ABL.
- The periodontitis group showed increased microvesicular steatosis and decreased NG2+ pericytes in the liver.
- Liver GSH levels were lower, and MDA concentrations were higher in the periodontitis group.
Conclusions:
- Induced periodontitis leads to liver changes like steatosis, likely due to oxidative stress and lipid peroxidation.
- A decrease in hepatic pericytes is associated with liver disease resulting from periodontitis in rats.
