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[Bone quality in COPD.]
Mitsuru Saito1, Keishi Marumo1
1Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
Clinical Calcium
|September 27, 2016
Summary
Chronic obstructive pulmonary disease (COPD) increases fracture risk due to impaired bone quality. Collagen crosslinking, affected by oxidative stress and glycation, may explain this bone deterioration in COPD patients.
Area of Science:
- Biomedical science
- Orthopedics
- Pulmonology
Background:
- Chronic obstructive pulmonary disease (COPD) is linked to higher fracture risk.
- Bone strength depends on mass and quality, including structural and material properties.
- Collagen crosslinking is crucial for bone strength.
Purpose of the Study:
- To investigate the role of collagen crosslinking in bone quality deterioration in COPD.
- To explore the impact of oxidative stress and glycation on collagen crosslinking in COPD.
Main Methods:
- Analysis of lysyl oxidase control.
- Assessment of non-enzymatic cross-links (advanced glycation end products, AGEs, pentosidine) in collagen.
- Comparison between patients with osteoporotic femoral neck fracture, diabetes, and COPD.
Main Results:
- Quantitative and qualitative deterioration of collagen crosslinking observed.
- Potential impact of increased oxidative stress and glycation on collagen crosslinking in COPD patients.
Conclusions:
- Collagen crosslinking abnormalities may contribute to increased fracture risk in COPD.
- Oxidative stress and glycation are potential mechanisms affecting bone quality in COPD.
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