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Peripheral Precocious Puberty due to Functioning Adrenocortical Tumor: Description of Two Cases
Lucia Ferrito1, Giovanni Cobellis2, Diana Giobbi3
1Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona, Ancona, Italy.
Journal of Pediatric and Adolescent Gynecology
|September 27, 2016
Summary
Adrenocortical tumors (ACTs) can cause virilization and peripheral precocious puberty (PPP) in children. Early diagnosis and treatment of ACTs are crucial to manage symptoms of androgen excess.
Area of Science:
- Pediatric Endocrinology
- Pediatric Oncology
Background:
- Adrenocortical tumors (ACTs) are rare childhood neoplasms.
- Common symptoms include virilization, hypercortisolism, and peripheral precocious puberty (PPP).
Observation:
- Two cases of prepubertal girls with ACTs presenting with virilization and PPP are described.
- Diagnosis was delayed by 5-6 months from symptom onset.
- Tumors were benign and surgically resected, but virilizing features persisted.
Findings:
- ACTs can manifest as virilization or PPP in prepubertal girls.
- Delayed diagnosis is common, impacting timely intervention.
- Complete tumor resection may not reverse established virilizing effects.
Implications:
- Adrenocortical tumors should be considered in the differential diagnosis of PPP.
- Prompt diagnosis and treatment are essential to mitigate androgen overproduction effects.
- Awareness of ACTs can improve early detection and management in pediatric patients.
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