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[Association between ambulatory arterial stiffness index with left ventricular mass index in the elderly hypertensive

H H Chen1, Y S Sun, M L Liu

  • 1Department of Geriatric, Peking University First Hospital, Beijing 100034, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|September 27, 2016
PubMed

Insights

Ambulatory arterial stiffness index (AASI) is linked to higher left ventricular mass index (LVMI) in elderly hypertensive patients. AASI may predict left ventricular hypertrophy in this population.

Area of Science:

  • Cardiology
  • Geriatrics
  • Hypertension Research

Background:

  • Arterial stiffness is a significant cardiovascular risk factor, particularly in elderly hypertensive patients.
  • Left ventricular hypertrophy (LVH) is a common complication of hypertension, associated with increased cardiovascular morbidity and mortality.
  • The ambulatory arterial stiffness index (AASI) is a non-invasive measure of arterial stiffness.

Purpose of the Study:

  • To investigate the relationship between AASI and left ventricular mass index (LVMI) in elderly hypertensive patients.
  • To determine if AASI is an independent predictor of LVH in this cohort.

Main Methods:

  • A study of 332 elderly hypertensive patients.
  • AASI measured via 24-hour ambulatory blood pressure monitoring.
  • LVMI assessed by echocardiography.
  • Statistical analyses included t-tests, Chi-square tests, Pearson correlation, and multivariate linear regression.

Main Results:

  • LVMI was significantly higher in patients with high AASI compared to those with low AASI (115.91±21.36 vs. 104.11±17.24 g/m², P=0.008).
  • AASI and 24-hour pulse pressure positively correlated with LVMI (r=0.332, P<0.001; r=0.169, P=0.002).
  • Multivariate analysis revealed AASI as an independent predictor of LVMI (β=44.48, P<0.001).

Conclusions:

  • AASI is independently associated with LVMI in elderly hypertensive patients.
  • AASI may serve as a valuable predictor of left ventricular hypertrophy in hospitalized elderly hypertensive individuals.

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