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[The poor chemotherapeutic efficacy in lung adenocarcinoma overexpressing c-Src and nucleophosmin/B23(NPM1)]
Jianbin He1, Zhi Xiang1, Jiwen Xiao2
1Department of Respiration Medicine, Huaihua 418000, China.
Abstract:
Objective To observe the expressions of c-Src protein and nucleophosmin/B23 (NPM1) protein in lung adenocarcinoma tissues and explore their relationships with chemotherapeutic efficacy. Methods The study collected a total of 107 lung adenocarcinoma tissue specimens from the First People's Hospital of Huaihua City from 2012-10-10 to 2015-06-30. Immunohistochemistry was used to analyze the expressions of c-Src protein and NPM1 protein. The relationships between the protein expressions and lung adenocarcinoma progression were subsequently analyzed. Among these patients, 55 cases of III-IV patients were treated with gemcitabine combined with cisplatin for 4 cycles of chemotherapy. The relationships between the protein expressions and chemotherapeutic efficacy were then analyzed. Results Both c-Src protein and NPM1 protein were positively expressed in lung adenocarcinoma tissues. With the increase of clinical stages, their expression levels gradually increased. However, their levels showed an inverse correlation with tumor differentiation degree. Chemotherapeutic efficacy decreased with the increase of the protein expressions. Conclusion Chemotherapeutic sensitivity is poor in lung adenocarcinoma patients overexpressing c-Src and NPM1 protein. High expressions of c-Src and NPM1 may be associated with poorly differentiated adenocarcinoma.
Insights
Lung adenocarcinoma patients with high c-Src and nucleophosmin/B23 (NPM1) protein expression show poor response to chemotherapy. These protein levels correlate with advanced stages and poor differentiation in lung cancer.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Lung adenocarcinoma is a major type of non-small cell lung cancer.
- Understanding molecular markers can improve treatment strategies.
- c-Src and nucleophosmin/B23 (NPM1) are proteins implicated in cancer progression.
Purpose of the Study:
- To investigate the expression of c-Src and NPM1 proteins in lung adenocarcinoma.
- To explore the association between these protein expressions and clinicopathological features.
- To determine the relationship between c-Src and NPM1 expression and chemotherapeutic efficacy.
Main Methods:
- Analysis of 107 lung adenocarcinoma tissue specimens.
- Immunohistochemistry to detect c-Src and NPM1 protein expression.
- Correlation analysis with clinical stage, differentiation, and chemotherapy response.
Main Results:
- c-Src and NPM1 proteins were overexpressed in lung adenocarcinoma tissues.
- Expression levels increased with higher clinical stages and decreased with better differentiation.
- Higher expression of c-Src and NPM1 correlated with reduced chemotherapeutic efficacy.
Conclusions:
- Overexpression of c-Src and NPM1 is linked to poor chemotherapeutic sensitivity in lung adenocarcinoma.
- High c-Src and NPM1 expression may indicate poorly differentiated tumors.
- These proteins could serve as potential biomarkers for predicting treatment outcomes.
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