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Updated: Mar 14, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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[Neuropsychiatric Systemic Lupus Erythematosus].
1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health.
Brain and Nerve = Shinkei Kenkyu No Shinpo
|September 27, 2016
Summary
Neuropsychiatric lupus erythematosus (NPSLE) involves central nervous system damage, leading to severe outcomes. Current treatments focus on reducing damage with immunosuppressants and corticosteroids, while new therapies are under development.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Background:
- Central nervous system (CNS) damage is a significant manifestation of systemic lupus erythematosus (SLE), contributing to substantial morbidity and mortality.
- Neuropsychiatric SLE (NPSLE) encompasses CNS and peripheral nervous system involvement, presenting with diverse clinical features like stroke, seizures, and psychosis.
Purpose of the Study:
- To summarize current understanding and treatment strategies for NPSLE.
- To highlight the need for more effective and less toxic therapeutic options for NPSLE management.
Main Methods:
- Review of established diagnostic criteria for NPSLE.
- Analysis of current treatment paradigms, including high-dose corticosteroids and immunosuppressants (mycophenolate mofetil, cyclophosphamide).
- Consideration of treat-to-target strategies for SLE management.
Main Results:
- NPSLE treatment aims to control disease activity and minimize corticosteroid toxicity.
- Management includes addressing comorbidities, particularly cardiovascular risk factors.
- The development of novel treatments like biologics and kinase inhibitors is ongoing.
Conclusions:
- Effective NPSLE management requires a multi-faceted approach focusing on disease control and damage prevention.
- There is a continuous need for innovative therapies to improve patient outcomes and quality of life in NPSLE.
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