Related Experiment Video

Updated: Mar 14, 2026

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
06:04

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae

Published on: February 24, 2023

2.9K

Insights into the pathogenesis of Mycoplasma pneumoniae (Review)

Jun He1, Mihua Liu1, Zhufeng Ye1

  • 1Department of Clinical Laboratory, Nanhua Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China.

Molecular Medicine Reports
|September 27, 2016
PubMed

Insights

Mycoplasma pneumoniae, a common pathogen, causes pneumonia and various other systemic diseases. This review details its direct damage mechanisms, highlighting the complexity of its pathogenesis.

Area of Science:

  • Microbiology
  • Pathogen Research
  • Infectious Diseases

Background:

  • Mycoplasma are the smallest wall-less prokaryotes, capable of passing through filters.
  • Mycoplasma pneumoniae (M. pneumoniae) is a significant pathogen causing respiratory and systemic illnesses.
  • The complex pathogenesis of M. pneumoniae requires further elucidation.

Purpose of the Study:

  • To review the direct damage mechanisms of M. pneumoniae.
  • To summarize the multifaceted ways M. pneumoniae causes disease.
  • To provide a comprehensive overview of M. pneumoniae pathogenesis.

Main Methods:

  • Literature review of M. pneumoniae research.
  • Analysis of direct damage mechanisms.
  • Synthesis of current understanding of M. pneumoniae pathogenesis.

Main Results:

  • M. pneumoniae causes primary atypical and community-acquired pneumonia.
  • M. pneumoniae is linked to autoimmune hemolytic anemia, and affects the blood, cardiovascular, gastrointestinal, and skin systems.
  • It can also induce pericarditis, myocarditis, nephritis, and meningitis.
  • Direct damage mechanisms include adhesion, membrane fusion destruction, nutrient depletion, invasion, toxic effects, inflammation, and immune responses.

Conclusions:

  • M. pneumoniae exhibits diverse pathogenic mechanisms.
  • Understanding these direct damage pathways is crucial for comprehending M. pneumoniae infection.
  • Further research is essential to fully determine the detailed pathogenesis of M. pneumoniae.

More Related Videos

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

3.3K
Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

15.7K

Related Concept Videos

Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
3.8K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
1.2K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.9K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.1K