Related Experiment Videos
Interference with creatinine concentration measurement by high dose furosemide infusion
J L Murphy1, T L Hurt, W R Griswold
1Department of Pediatrics, University of California, San Diego, La Jolla 92093.
Critical Care Medicine
|September 1, 1989
Summary
High doses of furosemide can interfere with colorimetric serum creatinine tests. Enzymatic methods are recommended for accurate creatinine measurement in patients on high-dose furosemide therapy.
Area of Science:
- Clinical Chemistry
- Pharmacology
- Nephrology
Background:
- Serum creatinine is a key biomarker for assessing kidney function.
- Furosemide is a potent loop diuretic commonly used in managing fluid overload and hypertension.
- Accurate creatinine measurement is crucial for clinical decision-making.
Observation:
- Colorimetric methods for serum creatinine measurement yielded unmeasurable results in three patients.
- These patients were receiving high doses of furosemide concurrently.
Findings:
- High-dose furosemide interferes with colorimetric assays, leading to falsely unmeasurable serum creatinine levels.
- Enzymatic methods provide accurate serum creatinine measurements in patients receiving high-dose furosemide.
Implications:
- Clinicians should be aware of the potential interference of high-dose furosemide with colorimetric creatinine assays.
- Switching to enzymatic creatinine measurement methods is recommended for patients on high-dose furosemide.
- Ensuring accurate kidney function assessment is vital for optimizing patient treatment and outcomes.