Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

291
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
291
Lipid Absorption01:24

Lipid Absorption

3.3K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
3.3K
Absorption of Nutrients01:19

Absorption of Nutrients

9.0K
Absorption refers to taking dietary nutrients from the intestinal lumen for transportation throughout the body. After digestion in the small intestine, carbohydrates, proteins, and fats are broken down into simpler forms. These essential macronutrients and other vital substances, such as vitamins, minerals, and water, are then prepared for absorption into the bloodstream.
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
9.0K
Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

1.6K
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
1.6K
Drug Absorption: Overview01:17

Drug Absorption: Overview

2.5K
The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...
2.5K
Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

801
Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
801

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafast subwavelength CVD-graphene nanoheater for the generation of broadband photoacoustic waves.

Photoacoustics·2026
Same author

Neonatal Cholestasis Progressing to a Multisystem Syndrome With Liver Cirrhosis in Two Siblings With FARSA Deficiency: An Evolving Hepatological Phenotype.

JIMD reports·2025
Same author

Prediction of Pt, Ir, Ru, and Rh complexes light absorption in the therapeutic window for phototherapy using machine learning.

Journal of cheminformatics·2025
Same author

The Silent Threat-Alkali Foot Burn: A Case Report.

Annals of burns and fire disasters·2024
Same author

Machine Learning-Based Prediction of Reduction Potentials for Pt<sup>IV</sup> Complexes.

Journal of chemical information and modeling·2024
Same author

Triphenylboroxine stability under low-energy-electron interactions.

Physical chemistry chemical physics : PCCP·2022

Related Experiment Video

Updated: Mar 14, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.7K

Can lipid nanoparticles improve intestinal absorption?

M Mendes1, H T Soares2, L G Arnaut2

  • 1Pharmacometrics Group of the Centre for Neurosciences and Cell Biology (CNC), University of Coimbra, 3004-517 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.

International Journal of Pharmaceutics
|November 6, 2016
PubMed
Summary
This summary is machine-generated.

This study developed novel solid oral dosage forms using nanostructured lipid carriers (NLCs) co-encapsulating olanzapine and simvastatin. These polymer-coated NLCs demonstrated enhanced drug delivery and intestinal permeability, offering a versatile platform for oral drug formulation.

Keywords:
Co-encapsulationIntestinal permeabilityNanostructured lipid carriersPolymer coatingScale-upSpray-drying

More Related Videos

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.5K
The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
06:14

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

3.4K

Related Experiment Videos

Last Updated: Mar 14, 2026

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

18.7K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.5K
The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion
06:14

The Isolation of Flowing Mesenteric Lymph in Mice to Quantify In Vivo Kinetics of Dietary Lipid Absorption and Chylomicron Secretion

Published on: November 30, 2022

3.4K

Area of Science:

  • Pharmaceutical Technology
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Lipid nanoparticles (NLCs) are promising nanocarriers for drug delivery.
  • Combining NLCs with conventional coating technologies offers product differentiation.
  • Developing solid dosage forms for oral administration requires innovative approaches.

Purpose of the Study:

  • To develop an innovative solid dosage form for oral administration using tableted nanostructured lipid carriers (NLCs).
  • To co-encapsulate olanzapine and simvastatin within NLCs (Combo-NLC) and evaluate their performance.
  • To modify NLCs with conventional polymer agents for controlled release and enhanced delivery.

Main Methods:

  • Production of NLC dispersions co-encapsulating olanzapine and simvastatin (Combo-NLC) via high-pressure homogenization.
  • Scalability assessment using factorial design.
  • Spray-drying for obtaining dry NLC particles and subsequent polymer coating.
  • In vitro release, cytotoxicity, and intestinal permeability studies.

Main Results:

  • Scalable production of NLCs was confirmed to be feasible.
  • Spray-drying facilitated efficient polymer coating of NLCs.
  • Polymer-modified NLCs achieved distinct release profiles (immediate, delayed, prolonged).
  • Sureteric:Combo-NLC showed low cytotoxicity and significantly enhanced intestinal permeability (12-fold for olanzapine, 3-fold for simvastatin) compared to commercial tablets.

Conclusions:

  • Nanostructured lipid carriers (NLCs) represent a versatile platform for developing modified solid oral dosage forms.
  • Polymer-coated Combo-NLCs offer improved drug protection and controlled release.
  • This innovative approach enhances drug intestinal permeability, suggesting potential for improved therapeutic outcomes.