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Published on: September 23, 2025
The Application of Frailty to the Modern Cardiac Risk Assessment: a Case-Based Review
1Department of Cardiology, Columbia University Medical Center, New York, NY, USA ; Division of Cardiology, 622 West 168th Street, PH 3-347, New York, NY 10032, USA.
Insights
Frailty assessment is crucial for older adults undergoing cardiac evaluations. Incorporating frailty data improves risk prediction and shared decision-making for cardiovascular procedures.
Area of Science:
- Cardiology
- Geriatrics
- Clinical Risk Assessment
Background:
- Cardiac risk assessment in aging populations is complex, especially concerning invasive procedures.
- Frailty is a recognized predictor of adverse outcomes in cardiovascular conditions like coronary artery disease, heart failure, and aortic stenosis.
Purpose of the Study:
- To review current clinical trial data on the impact of frailty in cardiovascular disease patients.
- To provide a case-based appraisal for clinicians.
- To enhance shared decision-making in cardiac care for older adults.
Main Methods:
- Systematic review of existing clinical trial data.
- Case-based appraisal of frailty's impact on cardiovascular disease outcomes.
- Focus on data relevant to practicing clinicians.
Main Results:
- Frailty is consistently associated with poorer outcomes in patients with various cardiovascular diseases.
- Integrating frailty assessment can refine cardiac risk stratification.
- Evidence supports frailty as a key factor in managing aging cardiac patients.
Conclusions:
- Frailty is an essential consideration in cardiac risk assessment for older adults.
- Utilizing frailty data improves the accuracy of risk prediction and patient-physician decision-making.
- Further integration of frailty assessment into clinical practice is recommended for cardiovascular care.
Abstract:
Cardiac risk assessment in aging patients poses a significant challenge to the practicing clinician, particularly when evaluating the use of invasive procedures. Frailty is a valuable risk marker that has been associated with worse outcomes in patients with coronary artery disease, heart failure, and aortic stenosis. Integrating the available frailty studies into cardiac risk assessments can help improve shared decision-making between physicians and their patients. In this review, we provide an up-to-date, case-based appraisal of the available clinical trial data focusing on the impact of frailty in patients with cardiovascular disease.
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