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Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Plasma endocan level and prognosis of immunoglobulin A nephropathy

Yu Ho Lee1, Jin Sug Kim1, Se-Yun Kim1

  • 1Division of Nephrology, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Kidney Research and Clinical Practice
|September 27, 2016
PubMed

Insights

Plasma and urine endocan levels are elevated in immunoglobulin A nephropathy (IgAN) patients. High plasma endocan is an independent risk factor for chronic kidney disease (CKD) progression in IgAN.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Vascular Biology

Background:

  • Endocan (endothelial cell-specific molecule-1) is a soluble proteoglycan secreted by vascular endothelial cells.
  • Elevated plasma endocan is linked to adverse cardiovascular outcomes in chronic kidney disease (CKD).
  • The clinical significance of endocan in immunoglobulin A nephropathy (IgAN) remains to be fully elucidated.

Purpose of the Study:

  • To investigate the clinical relevance of plasma and urine endocan levels in patients with IgAN.
  • To determine the association between endocan levels and disease severity, renal function, and long-term renal outcomes in IgAN.

Main Methods:

  • A cohort of 64 IgAN patients and 20 healthy controls were recruited.
  • Plasma and urine endocan levels were quantified using validated assays.
  • Clinical parameters, pathological findings, and renal outcomes were analyzed in relation to endocan levels.

Main Results:

  • IgAN patients exhibited significantly higher plasma and urine endocan levels compared to controls.
  • Elevated C-reactive protein and serum phosphorus were independent predictors of plasma endocan.
  • High plasma endocan levels were associated with adverse renal outcomes and predicted CKD progression in IgAN patients.
  • Urine endocan levels correlated with impaired renal function.

Conclusions:

  • Plasma and urine endocan levels are elevated in IgAN.
  • Plasma endocan serves as a potential independent prognostic biomarker for predicting CKD progression in IgAN patients.
Abstract

Keywords:
EndocanEndothelial cell–specific molecule-1Immunoglobulin A nephropathy

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