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Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
Published on: March 9, 2019
Data on combination effect of PEG-coated gold nanoparticles and non-thermal plasma inhibit growth of solid tumors
Nagendra Kumar Kaushik1, Neha Kaushik2, Ki Chun Yoo3
1Plasma Bioscience Research Center / Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 139-701 Korea.
Abstract:
Highly resistant tumor cells are hard to treat at low doses of plasma. Therefore, researchers have gained more attention to development of enhancers for plasma therapy. Some enhancers could improve the efficacy of plasma towards selectivity of cancer cells damage. In this dataset, we report the application of low doses of PEG-coated gold nanoparticles with addition of plasma treatment. This data consists of the effect of PEG-coated GNP and cold plasma on two solid tumor cell lines T98G glioblastoma and A549 lung adenocarcinoma. Cell proliferation, frequency of cancer stem cell population studies by this co-treatment was reported. Finally, we included in this dataset the effect of co-treatment in vivo, using tumor xenograft nude mice models. The data supplied in this article supports the accompanying publication "Low doses of PEG-coated gold nanoparticles sensitize solid tumors to cold plasma by blocking the PI3K/AKT-driven signaling axis to suppress cellular transformation by inhibiting growth and EMT" (N. K. Kaushik, N. Kaushik, K. C. Yoo, N Uddin, J. S. Kim, S. J. Lee et al., 2016) [1].
Insights
This study shows that PEG-coated gold nanoparticles enhance cold plasma therapy for resistant solid tumors. This combination treatment effectively reduces cancer cell growth and stem cell populations in vitro and in vivo.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Research
Background:
- Highly resistant tumor cells pose a significant challenge for conventional plasma therapy at low doses.
- Development of effective enhancers is crucial to improve plasma therapy's efficacy and selectivity against cancer cells.
Purpose of the Study:
- To investigate the synergistic effects of PEG-coated gold nanoparticles (GNP) and cold plasma on solid tumor cell lines.
- To evaluate the impact of this co-treatment on cancer cell proliferation, cancer stem cell frequency, and tumor growth in vivo.
Main Methods:
- Co-treatment of T98G glioblastoma and A549 lung adenocarcinoma cell lines with low-dose PEG-coated GNP and cold plasma.
- Assessment of cell proliferation and cancer stem cell population frequency.
- In vivo studies using tumor xenograft nude mice models to evaluate co-treatment efficacy.
Main Results:
- PEG-coated GNP sensitize solid tumors to cold plasma, enhancing cancer cell damage.
- The co-treatment effectively suppressed tumor growth and reduced cancer stem cell populations.
- Inhibition of the PI3K/AKT signaling pathway was observed, leading to suppressed cellular transformation, growth, and epithelial-mesenchymal transition (EMT).
Conclusions:
- Low doses of PEG-coated gold nanoparticles combined with cold plasma offer a promising strategy for treating resistant solid tumors.
- This approach enhances plasma therapy's effectiveness by targeting key cancer-promoting signaling pathways.
- The findings support the potential of nanoparticle-enhanced plasma therapy for improved cancer treatment outcomes.
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