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Updated: Mar 14, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Efficacy and Safety of Treating Glioblastoma With Tumor-Treating Fields Therapy
Marlon G Saria1, Santosh Kesari1
1John Wayne Cancer Institute at Providence Saint John's Health Center.
Background:
Glioblastoma (GBM) is a highly aggressive astrocytoma with a dismal prognosis. Since 1976, only three chemotherapeutic agents have been approved for the treatment of GBM. Tumor-treating fields (TTFields) therapy, delivered via a noninvasive device, is a new therapy approved for use in patients with recurrent GBM and in combination with temozolomide for the treatment of newly diagnosed GBM.
Objectives:
This article reviews the mechanism of action and findings from preclinical and clinical studies supporting the use of TTFields for patients with newly diagnosed and recurrent GBM.
Methods:
This article provides an overview of published literature on the efficacy and safety of treating GBM with TTFields.
Findings:
For the first time in more than a decade, patients with GBM have a noninvasive treatment option that has been shown to increase progression-free survival and overall survival with minimal adverse events.
