Related Experiment Video
Updated: Mar 14, 2026
Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
Published on: June 16, 2023
Effect of Structured Physical Activity on Overall Burden and Transitions Between States of Major Mobility Disability
Thomas M Gill1, Jack M Guralnik1, Marco Pahor1
1From Yale School of Medicine, New Haven, Connecticut; University of Maryland School of Medicine, Baltimore, Maryland; University of Florida, Gainesville, Florida; Pennington Biomedical Research Center, Baton Rouge, Louisiana; Tufts University, Boston, Massachusetts; Stanford School of Medicine, Stanford, California; Wake Forest University and Wake Forest School of Medicine, Winston-Salem, North Carolina; University of Pittsburgh, Pittsburgh, Pennsylvania; and Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Background:
The total time a patient is disabled likely has a greater influence on his or her quality of life than the initial occurrence of disability alone.
Objective:
To compare the effect of a long-term, structured physical activity program with that of a health education intervention on the proportion of patient assessments indicating major mobility disability (MMD) (that is, MMD burden) and on the risk for transitions into and out of MMD.
Design:
Single-blinded, parallel-group, randomized trial. (ClinicalTrials.gov: NCT01072500).
Setting:
8 U.S. centers between February 2010 and December 2013.
Participants:
1635 sedentary persons, aged 70 to 89 years, who had functional limitations but could walk 400 m.
Intervention:
Physical activity (n = 818) and health education (n = 817).
Measurements:
MMD, defined as the inability to walk 400 m, was assessed every 6 months for up to 3.5 years.
Results:
During a median follow-up of 2.7 years, the proportion of assessments showing MMD was substantially lower in the physical activity (0.13 [95% CI, 0.11 to 0.15]) than the health education (0.17 [CI, 0.15 to 0.19]) group, yielding a risk ratio of 0.75 (CI, 0.64 to 0.89). In a multistate model, the hazard ratios for comparisons of physical activity with health education were 0.87 (CI, 0.73 to 1.03) for the transition from no MMD to MMD; 0.52 (CI, 0.10 to 2.67) for no MMD to death; 1.33 (CI, 0.99 to 1.77) for MMD to no MMD; and 1.92 (CI, 1.15 to 3.20) for MMD to death.
Limitation:
The intention-to-treat principle was maintained for MMD burden and first transition out of no MMD, but not for subsequent transitions.
Conclusion:
A structured physical activity program reduced the MMD burden for an extended period, in part through enhanced recovery after the onset of disability and diminished risk for subsequent disability episodes.
Primary Funding Source:
National Institute on Aging, National Institutes of Health.
