Related Experiment Video

Updated: Mar 14, 2026

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
09:24

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer

Published on: September 13, 2018

9.6K

Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative

Philipp H Baldia1, Angela Maurer1, Timon Heide1

  • 1Institute of Pathology, RWTH Aachen University, Aachen, Germany.

Oncotarget
|September 28, 2016
PubMed

Insights

Fibroblast growth factor receptor 3 (FGFR3) mutations in squamous differentiated bladder cancer are linked to overexpression and poor outcomes. These findings suggest FGFR3-targeted therapies may benefit this patient subgroup.

Area of Science:

  • Oncology
  • Genetics
  • Urology

Background:

  • Drugable fibroblast growth factor receptor (FGFR) alterations are known in squamous cell carcinomas (SCC).
  • FGFR modifications in squamous differentiated bladder cancer remain understudied.
  • This study investigates FGFR1-3 as potential therapeutic targets in this bladder cancer subtype.

Purpose of the Study:

  • To evaluate fibroblast growth factor receptor (FGFR) 1-3 alterations in squamous differentiated bladder cancer.
  • To assess FGFRs as potential therapeutic targets in this specific bladder cancer subgroup.
  • To correlate FGFR alterations with clinical outcomes.

Main Methods:

  • Analysis of 73 squamous differentiated bladder cancers for FGFR1-3 protein expression, copy number variations, and FGFR3 rearrangements (FISH).
  • Investigated FGFR3 mutations using SNapShot analysis.
  • Compared findings with The Cancer Genome Atlas (TCGA) data for the 'squamous-like' subtype.

Main Results:

  • FGFR3 overexpression observed in 9.4% of cases.
  • FGFR3 mutations (p.S249C) found in 8.5% of tumors, significantly associated with overexpression and poor prognosis.
  • TCGA data confirmed high FGFR3 expression and mutations in the 'squamous-like' subtype.

Conclusions:

  • FGFR3 mutations and overexpression are key findings in squamous differentiated bladder cancer.
  • These alterations correlate with unfavorable clinical outcomes.
  • FGFR3-targeted therapies show promise for this specific bladder cancer subgroup.
Keywords:
FGFR1FGFR2FGFR3fibroblast growth factor receptorsquamous bladder cancer

More Related Videos

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts09:43

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

942
A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

5.2K

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.3K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.2K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.8K