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Related Experiment Videos

Postprandial serum gastrin concentrations in normal foals.

G B Smyth1, D W Young, J Schumacher

  • 1Department of Large Animal Surgery, College of Veterinary Medicine, Auburn University, AL 36849-5522.

Equine Veterinary Journal
|July 1, 1989
PubMed
Summary

Serum gastrin levels in foals increase after feeding, especially in newborns. This response diminishes with age, with no significant postprandial increase observed in three-month-old foals.

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Area of Science:

  • Veterinary Medicine
  • Animal Physiology
  • Endocrinology

Background:

  • Gastrin plays a crucial role in gastrointestinal function.
  • Understanding gastrin dynamics in foals is important for assessing digestive health.
  • Limited data exists on the age-related changes in postprandial gastrin concentrations in foals.

Purpose of the Study:

  • To investigate the changes in serum gastrin concentrations after feeding in foals of different ages.
  • To determine the developmental pattern of postprandial gastrin response in young horses.

Main Methods:

  • Serum gastrin levels were measured in six foals at 1 day, 1 week, 1 month, and 3 months of age.
  • Blood samples were collected before feeding and at 30-minute intervals for 3 hours post-feeding.

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  • Foals were fasted for 2 hours before a 15-minute feeding (suckling) period.

    • Main Results:

    • Feeding significantly increased serum gastrin concentrations in foals at 1 day, 1 week, and 1 month of age.
    • The most substantial gastrin increase occurred in one-day-old foals.
    • No significant postprandial increase in serum gastrin was observed in 3-month-old foals.
    • Mean pre-feeding gastrin levels showed a slight decrease with age.
    • Peak postprandial gastrin levels were observed at 60 minutes post-feeding on day one and at one month of age.

    Conclusions:

    • Foals exhibit a strong postprandial gastrin response that matures and diminishes with age.
    • The decline in gastrin response by three months may be linked to G cell maturation, altered gastrin metabolism, or changes in gastrointestinal motility.
    • Further research is needed to elucidate the precise mechanisms underlying these age-related changes in gastrin dynamics.