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Updated: Mar 14, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

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Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents

Supaluk Prachayasittikul1, Ratchanok Pingaew2, Apilak Worachartcheewan1

  • 1Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

Mini Reviews in Medicinal Chemistry
|September 28, 2016
PubMed
Abstract

Insights

Pyridine and pyrimidine compounds are promising scaffolds for developing new anticancer drugs. Structural modifications enhance their potency, selectivity, and pharmacokinetic profiles for improved cancer treatment.

Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Pharmacology

Background:

  • Cancer poses a significant global health challenge, necessitating novel therapeutic agents.
  • Existing cancer treatments face limitations due to drug resistance and toxicity.
  • Pyridine and pyrimidine structures are integral to biological processes and cancer development, making them attractive drug discovery scaffolds.

Purpose of the Study:

  • To review the potential of pyridine and pyrimidine derivatives as anticancer agents.
  • To highlight structural modifications leading to enhanced drug properties.
  • To underscore the significance of these scaffolds in novel drug development.

Main Methods:

  • Literature review of pyridine and pyrimidine-based anticancer compounds.
  • Analysis of structural modifications and their impact on biological activity.
  • Discussion of pharmacokinetic profiles and toxicity considerations.

Main Results:

  • Recent advancements include structural modifications like substitution, conjugation, and metal coordination.
  • Pyridine and pyrimidine scaffolds demonstrate significant potential for developing potent and selective anticancer drugs.
  • These modifications aim to improve efficacy and reduce adverse effects.

Conclusions:

  • Pyridine and pyrimidine derivatives represent privileged scaffolds for anticancer drug discovery.
  • Their versatile structures allow for optimization of potency, selectivity, and pharmacokinetic properties.
  • Continued research into these compounds promises novel therapeutic strategies for cancer treatment.
Keywords:
Anticancer agentscancerfused-pyridine/pyrimidinemetal-based pyridine/pyrimidinepyridinepyrimidine

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