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Related Experiment Video

Updated: Mar 14, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

Tip60: Main Functions and Its Inhibitors.

Xiaoli Zhang¹, Jiyong Wu¹, Yepeng Luan²

¹Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.

Mini Reviews in Medicinal Chemistry

|September 28, 2016

Summary

Tip60, a key histone acetyltransferase, regulates vital cellular processes. Its dysfunction is linked to various cancers, and its inhibitors are summarized here.

Keywords:

Cancer HATs HDACs Tip60 histone acetyltransferase inhibitor ε-amino

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Area of Science:

Biochemistry
Molecular Biology
Epigenetics

Background:

Tip60 is a MYST family histone acetyltransferase interacting with HIV-1 Tat.
It acetylates histone and non-histone proteins, impacting cellular signaling, DNA repair, cell cycle, and apoptosis.

Purpose of the Study:

To summarize the main functions of Tip60.
To review known inhibitors of Tip60.

Main Methods:

Literature review of Tip60 functions.
Compilation of known Tip60 inhibitors.

Main Results:

Tip60 plays crucial roles in fundamental cellular processes.
Tip60 dysfunction is implicated in the development of various cancers.
Several inhibitors targeting Tip60 have been identified.

Conclusions:

Tip60 is a significant regulator of cellular functions with implications in cancer.
Understanding Tip60's role and its inhibitors is vital for therapeutic strategies.