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Updated: Mar 14, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Tip60: Main Functions and Its Inhibitors
Xiaoli Zhang1, Jiyong Wu1, Yepeng Luan2
1Department of Pharmacy, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
Background:
Tip60, the founding member of MYST histone acetyltransferase family, was originally identified as a cellular acetyltransferase protein that interacts with HIV-1 Tat. Tip60 plays roles in many processes such as cellular signaling transmission, DNA damage repair, cell cycle and checkpoint control and apoptosis by acetylating its histone or non-histone substrates.
Results:
Dysfunction of Tip60 could promote or suppress diseases including different kinds of cancers.
Conclusion:
Here, main functions and its known inhibitors were summarized.
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