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Related Concept Videos

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Updated: Mar 14, 2026

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells
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Gene Therapy and its Implications in Dentistry.

A R Prabhakar1, Jibi M Paul2, N Basappa3

  • 1Professor and Head, Department of Pedodontics and Preventive Dentistry, Bapuji Dental College and Hospital, Davangere, Karnataka, India.

International Journal of Clinical Pediatric Dentistry
|September 28, 2016
PubMed
Summary

Gene therapy, involving gene transfer, is advancing rapidly, offering new treatment possibilities beyond severe diseases. This review explores its progress and dental applications.

Keywords:
Bone repairCancerDNA vaccinationGene therapyGene transferKeratinocytesOrthodontic tooth movement.PainSalivary glands

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Genetics

Background:

  • Gene therapy, the transfer of genes for clinical use, has evolved significantly over decades.
  • Recombinant DNA technology has accelerated progress, expanding potential applications beyond life-threatening conditions.
  • Gene therapy is increasingly considered for non-life-threatening diseases impacting quality of life due to limited conventional treatments.

Purpose of the Study:

  • To review advancements in gene transfer strategies.
  • To examine the application of gene therapy for diseases and conditions relevant to dental practice.

Main Methods:

  • Review of scientific literature on gene transfer and therapy.
  • Analysis of progress in addressing genetic diseases and dental conditions.

Main Results:

  • Significant progress has been made in gene therapy techniques.
  • Challenges remain for routine clinical application of gene transfer.
  • Gene therapy shows promise for diverse biological science applications.

Conclusions:

  • Gene therapy is poised to have a substantial impact across biological sciences.
  • Further research is needed to overcome existing challenges for widespread clinical adoption.