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Related Experiment Video

Updated: Mar 14, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

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Split liver transplantation in adults.

Koji Hashimoto1, Masato Fujiki1, Cristiano Quintini1

  • 1Koji Hashimoto, Masato Fujiki, Cristiano Quintini, Federico N Aucejo, Teresa Diago Uso, Dympna M Kelly, Bijan Eghtesad, John J Fung, Charles M Miller, Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, United States.

World Journal of Gastroenterology
|September 28, 2016
PubMed
Summary

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Articles linked to this work by shared authors, journal, and citation graph.

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From Clinical Heterogeneity to National Standardization in Liver Transplantation for Perihilar Cholangiocarcinoma: The LITALHICA Protocol.

Transplantation·2026
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Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

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Modified Charlson Comorbidity Index to Improve Management of Patients with Hepatocellular Carcinoma: A Step Towards Multiparametric Approach.

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The Predictive Role of [18F]FDG PET/CT in Early HCC Recurrence After Liver Transplantation.

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Excellent outcomes of living donor liver transplantation: A contemporary report from Western Center.

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Long-term considerations following living liver donation-Guidelines from the 2025 ILTS-iLDLT consensus conference on living liver donor safety.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2025

Split liver transplantation (SLT) is underutilized in adults but offers outcomes comparable to traditional liver transplants when key requirements are met. Advancements enable wider graft use, though challenges remain.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Medical Ethics

Background:

  • Split liver transplantation (SLT) is established in pediatric cases but less common in adults.
  • Recent surgical and matching advancements allow expanded graft utilization in SLT.

Purpose of the Study:

  • To review the current status of adult SLT.
  • To discuss donor/recipient selection, surgical techniques, outcomes, and ethical considerations.

Main Methods:

  • Review of existing literature and clinical experience spanning over two decades.
  • Analysis of physiological donor/recipient matching criteria.
  • Evaluation of surgical techniques and outcomes.

Main Results:

  • Early SLT outcomes were less favorable, but experienced centers report improved results.
Keywords:
AdultsDonor and recipient selectionEthical issuesGraft sizeGraft survivalSplit liver transplantationSurgical technique

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  • Successful adult SLT can achieve outcomes equivalent to whole liver transplantation.
  • Key requirements for successful adult SLT have been identified.

    • Conclusions:

    • Adult SLT is feasible and effective when specific criteria are met.
    • Ongoing challenges in surgical techniques, logistics, and ethics hinder wider adoption.
    • Further expansion requires addressing these persistent barriers.