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Related Experiment Video

Updated: Mar 14, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Fully Regressive Melanoma: A Case Without Metastasis.

Eric Ehrsam¹, Joseph R Kallini², Damien Lebas¹

¹Service de dermatologie, université catholique de Lille, hôpital Saint-Vincent-de-Paul, Lille, France;

The Journal of Clinical and Aesthetic Dermatology

|September 28, 2016

Summary

Fully regressive melanoma, a rare condition where the primary tumor is replaced by scar tissue, was diagnosed in a patient without metastasis. This case highlights a unique presentation of cutaneous melanoma, confirmed by dermoscopy and biopsy.

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Area of Science:

Dermatology
Oncology
Pathology

Background:

Fully regressive melanoma is a rare phenomenon where the primary cutaneous melanoma is replaced by fibrotic tissue due to the host immune response.
While partial regression occurs in 10-35% of cutaneous melanomas, complete regression is exceptionally rare, with only 47 cases documented.
Most reported cases of fully regressive melanoma are associated with metastasis at diagnosis.

Observation:

This report details an unusual case of fully regressive melanoma.
The patient presented with no signs of metastasis at the time of diagnosis.
Key diagnostic features included characteristic dermoscopic findings and subsequent biopsy confirming the absence of melanoma.

Findings:

A rare case of fully regressive melanoma was identified.
The diagnosis was confirmed through characteristic dermoscopic patterns and a final biopsy.
Crucially, the patient had no metastases at the time of diagnosis, distinguishing it from previously reported cases.

Implications:

This case expands the understanding of fully regressive melanoma presentations.
It suggests that fully regressive melanoma can occur without metastasis.
Further research into the immune response in regressive melanoma is warranted.