Which SSRIs most effectively treat depression in adolescents?
Related Experiment Video
Updated: Mar 14, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Valory DeLucia1, Gary Kelsberg1, Sarah Safranek2
1Valley Family Medicine Residency, University of Washington at Renton, WA, USA.
Abstract:
We don't know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared these antidepressants with each other. Three SSRI antidepressant medications--fluoxetine, sertraline, and escitalopram--produce modest improvements (about 5% to 10%) in standardized depression scores without a significant increase in the risk of suicide-related outcomes (suicidal behavior or ideation) in adolescent patients with major depression of moderate severity.
More Related Videos
Related Concept Videos
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
Antidepressant Drugs: MAOIs and Other Agents
Antidepressant Drugs: Overview
Electroconvulsive Therapy
Drug Therapy
Antianxiety Medications
Treatment Strategies for Psychological Disorders
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...

