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Updated: Mar 14, 2026

Spatial Separation of Molecular Conformers and Clusters
Published on: January 9, 2014
Comparative structural and vibrational study of the four lowest energy conformers of serotonin
Omkant Jha1, T K Yadav1, R A Yadav1
1Laser and Spectroscopy Laboratory, Department of Physics, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Abstract:
A computational investigation of all possible lowest energy conformers of serotonin was carried out at the B3LYP/6-311++G** level. Out of the 14 possible lowest energy conformers, the first 4 conformers were investigated thoroughly for the optimized geometries, fundamental frequencies, the potential energy distributions, APT and natural charges, natural bond orbital (NBO) analysis, MEP, Contour map, total density array, HOMO, LUMO energies. The second third and fourth conformers are energetically at higher temperatures of 78, 94 and 312K respectively with respect to the first one. Bond angles and bond lengths do not show significant variations while the dihedral angles vary significantly in going from one conformer to the other. Some of the vibrational modes of the indole moiety are conformation dependent to some extent whereas most of the normal modes of vibration of amino-ethyl side chain vary significantly in going from one conformer to conformer. The MEP for the four conformers suggested that the sites of the maximum positive and negative ESP change on changing the conformation. The charges at some atomic sites also change significantly from conformer to conformer.
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Stereoisomers
Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...