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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Isolation of Lamina Propria Mononuclear Cells from Murine Colon Using Collagenase E
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Leukaemoid reaction and ulcerative colitis.

P Merrin1, M J Lancaster Smith

  • 1Department of Gastroenterology, Queen Mary's Hospital, Sidcup, Kent.

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This summary is machine-generated.

A severe blood abnormality, known as a leukaemoid reaction, can occur with toxic dilatation of the colon due to ulcerative colitis. Treating the underlying inflammatory bowel disease resolved this significant hematologic issue.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Internal Medicine

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Toxic dilatation of the colon is a rare but serious complication of UC.
  • Hematologic abnormalities can occur in inflammatory conditions.

Observation:

  • A patient presented with significant neutrophil leukocytosis and a leukaemoid reaction.
  • This hematologic finding was associated with toxic dilatation of the colon.
  • The bowel disturbance was previously unrecognized.

Findings:

  • The pronounced neutrophil leukocytosis and leukaemoid reaction were secondary to toxic dilatation of the colon.
  • Treatment of the underlying ulcerative colitis led to the resolution of the hematologic abnormality.
  • This case highlights the connection between gastrointestinal inflammation and systemic hematologic changes.

Implications:

  • Recognizing bowel disturbances is crucial in patients with ulcerative colitis.
  • Prompt treatment of inflammatory bowel disease can reverse associated hematologic complications.
  • This case underscores the importance of a multidisciplinary approach in managing complex gastrointestinal and hematologic conditions.