Related Experiment Video
Updated: Mar 14, 2026

Assembly and Purification of Prototype Foamy Virus Intasomes
Published on: March 19, 2018
Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant
Yu Zhao1, Qiong Gu1,2, Susan L Morris-Natschke1
1Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina , Chapel Hill, North Carolina 27599-7568, United States.
Abstract:
Two "privileged fragments", caffeic acid and piperazine, were integrated into bevirimat producing new derivatives with improved activity against HIV-1/NL4-3 and NL4-3/V370A carrying the most prevalent bevirimat-resistant polymorphism. The activity of one of these, 18c, was increased by 3-fold against NL4-3 and 51-fold against NL4-3/V370A. Moreover, 18c is a maturation inhibitor with improved metabolic stability. Our study suggested that integration of privileged motifs into promising natural product skeletons is an effective strategy for discovering potent derivatives.
Related Concept Videos
Retroviruses
Size and Structure of Viral Genomes
Subviral Agents
Retrovirus Life Cycles

