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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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Pharmacokinetics, lineage identity, and trafficking of ex vivo expanded polyclonal regulatory T cells in a prospective randomized clinical trial of kidney transplant recipients with allograft inflammation.

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Related Experiment Video

Updated: Mar 14, 2026

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
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Advances in diagnostics for transplant rejection.

Michael Nasr1,2,3, Tara Sigdel1,4, Minnie Sarwal1,4

  • 1a Sarwal Lab , University of California, San Francisco , San Francisco , CA , USA.

Expert Review of Molecular Diagnostics
|September 29, 2016
PubMed
Summary

Early detection of allograft injury is crucial for transplant longevity. Molecular diagnostics offer promising biomarkers for personalized transplant management and earlier rejection detection.

Keywords:
Molecular diagnosticsacute rejectiongenomicsgraft monitoringindicators of immune responseorgan transplantationpersonalized transplant managementproteomicstranscriptomics

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Non-invasive Imaging of Acute Allograft Rejection after Rat Renal Transplantation Using 18F-FDG PET
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Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
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Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

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Area of Science:

  • Transplant immunology
  • Molecular diagnostics
  • Biomarker discovery

Background:

  • Allograft injury, including acute rejection, significantly risks transplanted organ longevity.
  • Immune and non-immune factors contribute to acute rejection.
  • Early detection of allograft injury is vital for increasing transplanted organ survival.

Purpose of the Study:

  • To review advancements in molecular diagnostics for allograft injury.
  • To highlight the potential of new biomarkers for personalized transplant management.
  • To discuss challenges and future directions in the field.

Main Methods:

  • Comprehensive keyword searches of full-text publications.
  • Review of genomic, transcriptomic, and proteomic biomarker discoveries.
  • Analysis of current diagnostic methodologies.

Main Results:

  • Numerous novel molecular diagnostic biomarkers show promise for early allograft injury detection.
  • Genomic, transcriptomic, and proteomic approaches offer enhanced potential for personalized management.
  • Advancements facilitate earlier identification of rejection episodes.

Conclusions:

  • Further validation in larger cohorts is necessary for clinical realization of new biomarkers.
  • Differentiating injury causes is critical for informed therapeutic decisions.
  • Multiplexing methodologies are being explored for robust biomarker development.