Related Experiment Video

Updated: Mar 14, 2026

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.9K

Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure

Joseph F Hagan1, Tatiana Balachova2, Jacquelyn Bertrand3

  • 1University of Vermont College of Medicine, Burlington, Vermont; jhagan@aap.net.

Pediatrics
|September 29, 2016
PubMed

Insights

Children exposed to alcohol prenatally may have neurobehavioral disorder associated with prenatal exposure, impacting neurocognition and self-regulation. Pediatric clinicians can identify, diagnose, and manage these children within medical homes.

Area of Science:

  • Neuroscience
  • Pediatric Medicine
  • Developmental Psychology

Background:

  • Prenatal alcohol exposure can cause brain damage leading to neurodevelopmental challenges.
  • Children may exhibit impairments in neurocognition, self-regulation, and adaptive functioning.
  • A specific diagnosis, neurobehavioral disorder associated with prenatal exposure (ND-PAE), is increasingly recognized.

Purpose of the Study:

  • To provide clinical guidelines for pediatric medical home clinicians.
  • To outline strategies for identifying and diagnosing ND-PAE in children.
  • To offer guidance on managing affected children and obtaining prenatal alcohol exposure history.

Main Methods:

  • Review of clinical presentations and diagnostic criteria for ND-PAE.
  • Emphasis on observable behaviors within pediatric medical home settings.
  • Discussion of differential diagnosis and common comorbidities.

Main Results:

  • Children with prenatal alcohol exposure may present with a distinct pattern of neurodevelopmental deficits.
  • Pediatric medical homes are crucial for early identification and intervention.
  • Management requires a comprehensive approach addressing cognitive, behavioral, and adaptive needs.

Conclusions:

  • Early identification and diagnosis of ND-PAE are essential for affected children.
  • Pediatric medical homes play a vital role in the care continuum for these patients.
  • Effective management strategies can improve outcomes for children with ND-PAE.

More Related Videos

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats11:01

Moderate Prenatal Alcohol Exposure and Quantification of Social Behavior in Adult Rats

Published on: December 14, 2014

10.3K
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure10:07

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure

Published on: March 20, 2012

27.2K

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.4K
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.5K
Intellectual Disability01:29

Intellectual Disability

Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
964
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.2K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.5K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
985