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A Murine Model of Group B Streptococcus Vaginal Colonization
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Mitral valve replacement in neonatal endocarditis: time to discuss prevention strategies for Group B streptococcus

Sormeh Salehian1, Abhinav Rastogi1, Olivier Ghez1

  • 1Paediatric Intensive Care Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

BMJ Case Reports
|September 29, 2016
PubMed

Insights

Group B streptococcus (GBS) can cause severe neonatal infections, including sepsis and meningitis. This case highlights a rare GBS-related infective endocarditis in a neonate, requiring complex treatment and valve replacement.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Cardiology

Background:

  • Group B streptococcus (GBS) is a primary cause of early-onset neonatal sepsis.
  • GBS can also lead to late-onset GBS septicaemia, meningitis, and rarely, infective endocarditis (IE).

Purpose of the Study:

  • To report a rare case of GBS septicaemia and meningitis in a neonate.
  • To describe the subsequent development and management of severe infective endocarditis in the same patient.

Main Methods:

  • Clinical case presentation and management.
  • Diagnostic procedures including blood cultures and echocardiography.
  • Surgical intervention for severe mitral valve infective endocarditis.

Main Results:

  • A healthy term neonate developed GBS septicaemia and meningitis.
  • The neonate subsequently developed severe infective endocarditis affecting the mitral valve.
  • Successful mitral valve replacement using an innovative Melody valve procedure.

Conclusions:

  • Group B streptococcus can cause severe, multi-system infections in neonates, including infective endocarditis.
  • Prompt diagnosis and aggressive management, including valve replacement, are crucial for survival.
  • Innovative valve replacement techniques offer viable solutions for complex neonatal cardiac conditions.

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