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In Situ Observation of Single-Molecule Surface Reactions from Low to High Affinities
Eugene Kim1, Martin D Baaske1, Frank Vollmer1
1Max Planck Institute for the Science of Light, Günther-Scharowsky-Straβe 1, 91058, Erlangen, Germany.
Abstract:
In situ observation of single-molecule surface reactions from low to high affinities is achieved by resonant coupling between optical whispering-gallery modes and the localized surface plasmon of nanorods. Transient and permanent interactions between ligands (thiol, amine) and the gold surface are monitored without labels, allowing direct determination of the associated kinetic constants and rapid development of new functionalization protocols.
