Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in intracranial pressure during machine and continuous haemofiltration.

A Davenport1, E J Will, A M Davison

  • 1Department of Renal Medicine, St. James's University Hospital, Leeds, U.K.

The International Journal of Artificial Organs
|July 1, 1989
PubMed
Summary

Continuous arterio-venous haemofiltration (CAVHF) is preferred over machine haemofiltration (MHF) for patients with hepatorenal failure. CAVHF did not increase intracranial pressure (ICP), unlike MHF, which showed a significant ICP rise.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urolithiasis and crystalluria in dogs with primary portal vein hypoplasia: a retrospective study (2010-2023).

The Journal of small animal practice·2026
Same author

Spectral broadening and compression of picosecond pulses in air using a multi-pass cell.

Optics express·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Laser damage of UV hafnia-based multilayer dielectric coatings at 355  nm wavelength.

Applied optics·2025
Same author

Relationship between Surgery and Trauma and Risk of Recurrence in Patients with an Associated First Venous Thrombotic Event: A Nested Case-Control Study.

Thrombosis and haemostasis·2025

Area of Science:

  • Nephrology
  • Hepatology
  • Intensive Care Medicine

Background:

  • Fulminant hepatic failure (FHF) and acute oliguric renal failure (AORF) present a critical clinical challenge.
  • Management of hepatorenal failure often requires renal replacement therapy.
  • Intracranial pressure (ICP) monitoring is crucial in critically ill patients with liver failure.

Purpose of the Study:

  • To compare the effects of machine haemofiltration (MHF) and continuous arterio-venous haemofiltration (CAVHF) on intracranial pressure (ICP) in patients with FHF and AORF.
  • To determine the optimal haemofiltration modality for managing acute hepatorenal failure.

Main Methods:

  • Nine consecutive patients with FHF and AORF were included.
  • Patients were treated with either MHF (n=6) or CAVHF (n=4).

Related Experiment Videos

  • Intracranial pressure (ICP) was monitored using a subdural catheter throughout the treatment duration (mean 56 hours).

    • Main Results:

    • MHF treatment led to a significant increase in mean ICP (8.9 to 14.8 mmHg, p<0.05).
    • CAVHF treatment did not show a significant increase in mean ICP (19.4 to 11.2 mmHg).
    • Eleven episodes of elevated ICP (>25 mmHg) occurred during MHF, requiring intervention, whereas none were recorded during CAVHF.

    Conclusions:

    • Continuous arterio-venous haemofiltration (CAVHF) is a safer and more effective modality than machine haemofiltration (MHF) for managing intracranial pressure in patients with acute hepatorenal failure.
    • CAVHF is recommended over MHF for patients experiencing both fulminant hepatic failure and acute oliguric renal failure.