Metastatic retinoblastoma of the mandible

Two cases of oral metastasis of retinoblastoma are reported. The first case was seen in Iraq and the second case in England. Review of the literautre revealed that when oral metastasis occurs, the prognosis must be considered to be grave; this was confirmed by Case 2. In each case there was metastasis in the symphyseal region, which followed enucleation of the affected orbit. Although the prognosis is poor, recent studies indicate that immunologic techniques may be useful to monitor the response to treatment of the primary lesion.