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Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Diffusion Weighted Imaging in Acute Attacks of Multiple Sclerosis.

Yasmin Davoudi1, Mohsen Foroughipour2, Reza Torabi3

  • 1Department of Radiology, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society
|September 29, 2016
PubMed
Summary

Diffusion weighted imaging (DWI) shows promise for diagnosing acute multiple sclerosis (MS) attacks, sometimes detecting lesions missed by contrast-enhanced MRI (CE-MRI). Combining both methods may improve diagnostic accuracy for MS.

Keywords:
Diffusion Magnetic Resonance ImagingMagnetic Resonance ImagingMultiple Sclerosis

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Area of Science:

  • Neurology
  • Radiology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a common autoimmune disorder affecting the central nervous system.
  • Accurate diagnosis of MS, particularly acute attacks, remains challenging despite existing imaging techniques.

Purpose of the Study:

  • To assess the diagnostic utility of diffusion weighted imaging (DWI) for acute MS attacks.
  • To compare the efficacy of DWI with contrast-enhanced MRI (CE-MRI) in diagnosing MS relapses.

Main Methods:

  • A cross-sectional study included seventy patients diagnosed with relapsing-remitting MS.
  • Both CE-MRI and DWI sequences were performed on all participants.
  • Analysis involved comparing positive rates and consistency between DWI and CE-MRI, and their relation to symptom onset time.

Main Results:

  • CE-MRI detected positive results in 87% of patients, while DWI identified 76%.
  • Concordant positive results were observed in 71.42% of patients; both were negative in 8.57%.
  • DWI identified three cases as positive where CE-MRI was negative, with no significant time-dependent relationship for either method.

Conclusions:

  • While CE-MRI shows a higher positive rate, DWI can detect acute MS lesions not visible on CE-MRI.
  • Combining DWI and CE-MRI may enhance the detection of acute MS attacks.
  • Integrated imaging approaches could lead to more accurate MS diagnoses.