Related Experiment Video
Updated: Mar 14, 2026
06:30
Using Phage Display to Develop Ubiquitin Variant Modulators for E3 Ligases
Published on: August 27, 2021
3.7K
Phage display as a promising approach for vaccine development
Leili Aghebati-Maleki1,2,3, Babak Bakhshinejad4, Behzad Baradaran1,3
1Immunology Research Center, Tabriz University of Medical sciences, Tabriz, Iran.
Journal of Biomedical Science
|September 30, 2016
Summary
Bacteriophages (phages) are promising vaccine delivery vehicles due to their stability, cost-effective production, and adjuvant properties. Phage display technology enhances vaccine development by presenting antigens on phage surfaces for potent immune responses.
Area of Science:
- Microbiology
- Immunology
- Biotechnology
Background:
- Bacteriophages (phages) are viruses that infect bacteria, showing potential as vaccine delivery systems.
- Phages offer advantages for vaccine design, including stability, scalability, cost-effectiveness, and adjuvant properties.
- Their long evolutionary relationship with mammals contributes to a favorable safety profile for phage-based vaccines.
Approach:
- Phage display technology enables the expression of multiple antigen copies on immunogenic phage particles.
- Combinatorial peptide libraries generated via phage display facilitate high-throughput screening for vaccine candidates.
- Biopanning strategies, including screening against convalescent antisera, identify potent vaccine targets and epitopes.
Key Points:
- Phage display vaccines elicit robust immune responses by presenting antigens on phage surfaces.
- Phage display is a versatile tool for identifying novel vaccine candidates against various diseases, especially microbial infections.
- Biopanning identifies mimotopes with high antigenicity and immunogenicity from diverse phage libraries.
Conclusions:
- Phage display technology has revolutionized vaccine discovery and production strategies.
- Current advancements indicate a bright future for diverse phage-based vaccine platforms.
- Phages represent a significant platform for developing innovative and effective vaccines.
Related Concept Videos
01:26DNA Bacteriophages
1.3K
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
1.3K
00:43Lysogenic Cycle of Bacteriophages
69.1K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
69.1K
01:30Lytic Cycle of Bacteriophages
79.4K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
79.4K