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Related Concept Videos

Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
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Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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Updated: Mar 14, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Adverse Reactions to Injectable Fillers.

Rebecca Fitzgerald1, Vince Bertucci2, Jonathan M Sykes3

  • 1University of California Los Angeles, Los Angeles, California.

Facial Plastic Surgery : FPS
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PubMed
Summary

Adverse events from cosmetic fillers are increasing due to widespread use and varied injector skill. Proper training and technique can prevent many complications, but early detection and treatment are crucial for minimizing sequelae.

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Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Plastic Surgery

Background:

  • Dermal filler injections are increasingly prevalent in aesthetic procedures.
  • Variability in injector skill levels poses a risk for adverse events.
  • Complications associated with dermal fillers can range in severity.

Purpose of the Study:

  • To highlight the rising incidence of adverse events related to dermal filler use.
  • To emphasize the importance of appropriate training and injection techniques in complication prevention.
  • To provide guidance on early detection and management of filler-related complications.

Main Methods:

  • This article is a review and expert opinion piece.
  • It synthesizes current understanding of filler-related adverse events.
  • It discusses preventative measures and management strategies.

Main Results:

  • Adverse events are expected to increase with the growing popularity and varied expertise in filler injections.
  • Many complications can be avoided through proper training and refined injection techniques.
  • Early identification and prompt treatment are essential for mitigating or resolving adverse outcomes.

Conclusions:

  • While preventative measures are paramount, adverse events can still occur even with skilled practitioners.
  • A proactive approach to recognizing and managing complications is vital for patient safety.
  • This article aims to support practitioners in managing filler-related adverse events effectively.