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Updated: Mar 14, 2026

Methods for In Vivo Biomechanical Testing on Brachial Plexus in Neonatal Piglets
Published on: December 19, 2019
The natural history and management of brachial plexus birth palsy
Kristin L Buterbaugh1, Apurva S Shah2
1Division of Orthopaedic Surgery, Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Wood Building Room 2307, Philadelphia, PA, 19104-4318, USA.
Insights
Brachial plexus birth palsy (BPBP) can cause upper extremity paralysis. Early identification of elbow flexion recovery guides microsurgical intervention for improved limb function.
Area of Science:
- Pediatric Orthopedics
- Pediatric Neurology
Background:
- Brachial plexus birth palsy (BPBP) results from brachial plexus traction injury during childbirth, leading to upper extremity paralysis.
- About 20% of affected children experience residual neurologic deficits, impacting long-term upper limb function.
- The variable natural history of BPBP necessitates optimized management strategies.
Approach:
- Diagnosis of BPBP is primarily clinical, without routine reliance on cross-sectional imaging.
- Physical examination is crucial for identifying candidates requiring microsurgical reconstruction.
- Recovery of antigravity elbow flexion by 3-6 months of age is a key indicator for surgical intervention.
Key Points:
- Microsurgical reconstruction, including nerve transfers and grafting, is effective for infants with BPBP.
- Secondary procedures like botulinum toxin injections, tendon transfers, and osteotomies can improve outcomes in older children.
- Both primary microsurgery and secondary procedures offer substantial functional improvements.
Conclusions:
- Early and accurate diagnosis of BPBP is essential for timely intervention.
- Physical examination findings, particularly antigravity elbow flexion, guide treatment decisions.
- A combination of microsurgical and secondary procedures can significantly enhance functional outcomes for children with BPBP.
Abstract:
Brachial plexus birth palsy (BPBP) is an upper extremity paralysis that occurs due to traction injury of the brachial plexus during childbirth. Approximately 20 % of children with brachial plexus birth palsy will have residual neurologic deficits. These permanent and significant impacts on upper limb function continue to spur interest in optimizing the management of a problem with a highly variable natural history. BPBP is generally diagnosed on clinical examination and does not typically require cross-sectional imaging. Physical examination is also the best modality to determine candidates for microsurgical reconstruction of the brachial plexus. The key finding on physical examination that determines need for microsurgery is recovery of antigravity elbow flexion by 3-6 months of age. When indicated, both microsurgery and secondary shoulder and elbow procedures are effective and can substantially improve functional outcomes. These procedures include nerve transfers and nerve grafting in infants and secondary procedures in children, such as botulinum toxin injection, shoulder tendon transfers, and humeral derotational osteotomy.
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