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Resting Heart Rate and Long-term Outcomes Among the African American Population: Insights From the Jackson Heart
Kishan S Parikh1, Melissa A Greiner1, Takeki Suzuki2
1Duke Clinical Research Institute, Durham, North Carolina.
Insights
Higher resting heart rate predicts worse outcomes, including mortality and heart failure hospitalizations, in African Americans. This finding in the Jackson Heart Study mirrors results from white populations, suggesting potential benefits from heart rate reduction interventions.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Elevated resting heart rate is linked to adverse outcomes in predominantly white populations.
- Its prognostic significance in African Americans, who have distinct cardiac profiles, is less understood.
Purpose of the Study:
- To assess the prognostic value of resting heart rate in a community-based African American cohort.
- To investigate the association between heart rate and mortality and heart failure hospitalizations.
Main Methods:
- Prospective analysis of 5261 African American participants in the Jackson Heart Study.
- Baseline heart rate assessed via 12-lead electrocardiogram, analyzed continuously and by quintiles.
- Cox proportional hazards regression models used to determine associations with all-cause mortality and heart failure hospitalization.
Main Results:
- Higher baseline heart rate (e.g., 73-118 bpm) correlated with increased prevalence of diabetes, hypertension, higher BMI, and less physical activity.
- An elevated heart rate, as a continuous variable, was associated with increased mortality (adjusted HR per 5 bpm increase: 1.14) and heart failure hospitalizations (adjusted HR per 5 bpm increase: 1.10).
Conclusions:
- Increased resting heart rate is a significant predictor of mortality and heart failure hospitalizations in African Americans.
- Findings align with those in white populations, highlighting the need for further research into heart rate-lowering interventions for this demographic.
Importance:
Increased resting heart rate is associated with worse outcomes in studies of mostly white populations, but its significance is not well established in African Americans persons whose cardiac comorbidities and structural abnormalities differ.
Objective:
To study the prognostic utility of heart rate in a community-based African American cohort in the Jackson Heart Study.
Design, Setting, And Participants:
A total of 5261 participants in the Jackson Heart Study, a prospective, community-based study in Jackson, Mississippi, were evaluated. Baseline heart rate was assessed by quintiles and as a continuous variable. All participants with baseline heart rate documented by a 12-lead electrocardiogram without pacing or atrial fibrillation noted on their baseline Jackson Heart Study examination were included in the study. Follow-up began September 26, 2000, and was completed December 31, 2011. Data analysis was performed from July to October 2015.
Main Outcomes And Measures:
Unadjusted and adjusted associations between heart rate and all-cause mortality and heart failure hospitalization using Cox proportional hazards regression models.
Results:
Of the 5261 individuals included in the analysis, 1921 (36.5%) were men; median (25th-75th percentile) age was 55.7 (45.4-64.8) years. Median (25th-75th percentile) baseline heart rate was 63 beats per minute (bpm) (57-71 bpm). The highest heart rate quintile (73-118 bpm) had higher rates of diabetes (398 [37.4%]; P < .001) and hypertension (735 [69.1%]; P < .001), higher body mass index (median [IQR], 32.4 [28.1-38.3]; P < .001), less physical activity (0 hours per week, 561 [52.8%]; P < .001), and lower β-blocker use (73 [6.9%]; P < .001) compared with lower quintiles. Caffeine intake (from 80.7 to 85.5 mg/d; P = .57) and left ventricular ejection fraction (from 62% to 62.3%; P = .01) were similar between groups. As a continuous variable, elevated heart rate was associated with increased mortality and heart failure hospitalizations, with adjusted hazard ratios for every 5-bpm increase of 1.14 (95% CI, 1.10-1.19) and 1.10 (95% CI, 1.05-1.16), respectively. Similar patterns were observed in comparisons between the highest and lowest quintiles.
Conclusions And Relevance:
Higher baseline heart rate was associated with increased mortality and heart failure hospitalizations among African American participants in the Jackson Heart Study. These findings are similar to those seen in white populations, but further study is needed to understand whether African American individuals benefit from interventions targeting heart rate reduction.
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