Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

827
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
827
Long-term Depression01:03

Long-term Depression

3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.5K
Long-term Depression01:05

Long-term Depression

33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.0K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.0K
Stress and Mental Health01:30

Stress and Mental Health

1.1K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Training adults with acquired brain injury how to help-seek when wayfinding: an understudied critical life skill.

Neuropsychological rehabilitation·2017
Same author

Randomized Trial of the Family Intervention: Telephone Tracking-Caregiver for Dementia Caregivers: Use of Community and Healthcare Resources.

Journal of the American Geriatrics Society·2016
Same author

Families and stroke: The clinical implications of research findings.

Topics in stroke rehabilitation·2016
Same author

Psychobehavioral problems other than depression in stroke.

Topics in stroke rehabilitation·2016
Same author

Psychopharmacology and stroke.

Topics in stroke rehabilitation·2016
Same author

Foreword.

Topics in stroke rehabilitation·2016
Same journal

Associations of neuropathic pain and pain catastrophizing with rehabilitation outcomes in patients with stroke.

Topics in stroke rehabilitation·2026
Same journal

Education level amplifies the mediating pathway of rehabilitation motivation between metacognition and quality of life in stroke survivors.

Topics in stroke rehabilitation·2026
Same journal

Cortical activation and functional connectivity during thumb-to-finger opposition in patients with stroke with varying functional levels: insights from fNIRS.

Topics in stroke rehabilitation·2026
Same journal

Cognitive strategies for improving activity-level outcomes post stroke: an integrative review.

Topics in stroke rehabilitation·2026
Same journal

Efficacy of repetitive transcranial magnetic stimulation combined with soft robotic glove training for slight-to-moderate post-stroke upper limb spasticity: a randomized controlled trial.

Topics in stroke rehabilitation·2026
Same journal

Common coping and collaborative management of stroke survivors' spousal caregivers: a moderated mediation model of illness perception and resilience.

Topics in stroke rehabilitation·2026
See all related articles

Related Experiment Video

Updated: Mar 14, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

10.9K

Depression and stroke.

Leonard Diller1, Duane S Bishop2

  • 1a Director, Behavioral Science Rusk Institute of Rehabilitation Medicine Professor, Clinical Rehabilitation Medicine New York University Medical Center New York , New York.

Topics in Stroke Rehabilitation
|September 30, 2016
PubMed
Summary
This summary is machine-generated.

Depression is common in stroke survivors, affecting over half of patients. Recent studies improve understanding of its causes, impact on recovery, and management strategies.

Keywords:
depressiondisabilityrehabilitationstroke

More Related Videos

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.6K
Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
05:08

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

1.6K

Related Experiment Videos

Last Updated: Mar 14, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

10.9K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.6K
Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits
05:08

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

1.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Depression following stroke has been recognized for decades but is now a focus of systematic research.
  • Prevalence estimates vary, with some studies indicating over 50% of stroke patients experience depression.
  • Advances in diagnostic criteria and understanding of contributing factors, including biological and post-stroke impairments, have enhanced our knowledge.

Purpose of the Study:

  • To systematically review the current understanding of depression in stroke patients.
  • To explore the contributing factors, diagnostic refinements, and impact on rehabilitation.
  • To summarize current management approaches for post-stroke depression.

Main Methods:

  • Literature review and synthesis of recent studies on post-stroke depression.
  • Analysis of diagnostic criteria, etiological factors (biological, cognitive, linguistic), and epidemiological data.
  • Examination of studies on the effects of depression on stroke rehabilitation and its long-term course.

Main Results:

  • Depression is a frequent complication of stroke, with significant impact on patient outcomes.
  • Understanding has improved through refined diagnostics and recognition of contributing factors like cognitive and linguistic deficits.
  • Research now addresses the influence of depression on rehabilitation and its temporal trajectory.

Conclusions:

  • Effective management of post-stroke depression requires a multi-faceted approach.
  • Key interventions include caregiver education, environmental modifications, patient/family education, psychotherapy, and pharmacotherapy.
  • Continued research is vital to optimize care for this vulnerable population.