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Related Concept Videos

Hormonal Regulation01:33

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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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Glomerular Filtration Rate and its Regulation01:28

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The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
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Related Experiment Video

Updated: Mar 14, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
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The nephron (pro)renin receptor: function and significance.

Nirupama Ramkumar1, Donald E Kohan2,3

  • 1Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, Utah; and nirupama.ramkumar@hsc.utah.edu.

American Journal of Physiology. Renal Physiology
|September 30, 2016
PubMed
Summary

The (pro)renin receptor (PRR) in the kidney

Keywords:
(pro)renin receptorangiotensin II

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Area of Science:

  • Nephrology
  • Renal Physiology
  • Molecular Biology

Background:

  • The (pro)renin receptor (PRR) is a key component of the renin-angiotensin system.
  • PRR also functions as an accessory molecule for the vacuolar H+-ATPase.
  • PRR is significantly expressed in the kidney, particularly in the distal nephron.

Purpose of the Study:

  • To review recent advancements in understanding nephron PRR function.
  • To explore the role of PRR in both healthy and diseased kidney conditions.
  • To highlight new insights from viable renal cell-specific PRR knockout mouse models.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of data from viable renal cell-specific PRR knockout mouse models.
  • Discussion of angiotensin II (ANG II)-dependent and -independent signaling pathways.

Main Results:

  • Viable renal cell-specific PRR knockout mice have enabled new research.
  • PRR in the nephron influences renal function through distinct signaling pathways.
  • These pathways involve both ANG II-dependent and -independent mechanisms.

Conclusions:

  • Recent studies using novel mouse models have clarified PRR's role in the nephron.
  • PRR significantly impacts kidney function and pathophysiology.
  • Further research into PRR signaling pathways is crucial for understanding renal health.