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Update on hypertrophic cardiomyopathy and a guide to the guidelines

Srijita Sen-Chowdhry1,2, Daniel Jacoby3, James C Moon1,4

  • 1Institute of Cardiovascular Science, University College London, Gower Street, London WC1E 6BT, UK.

Nature Reviews. Cardiology
|September 30, 2016
PubMed

Insights

Hypertrophic cardiomyopathy (HCM), a common inherited heart condition, may be more prevalent than previously thought. Current management strategies improve life expectancy for most patients with HCM.

Area of Science:

  • Cardiology
  • Genetics
  • Inherited Cardiovascular Disorders

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiovascular disorder, affecting approximately 1 in 500 people.
  • Prevalence may be underestimated due to limited recognition of early or incomplete phenotypic expressions.
  • Clinical features range from diastolic dysfunction to a 'burnt-out' phase, with mortality risks including sudden cardiac death, heart failure, and stroke.

Purpose of the Study:

  • To provide a comprehensive review of current clinical guidelines for hypertrophic cardiomyopathy (HCM).
  • To highlight updates, knowledge gaps, and implementation challenges in HCM management.
  • To discuss advancements in genetics, imaging, and molecular research for future diagnosis and therapy.

Main Methods:

  • Review of existing epidemiological data and clinical manifestations of HCM.
  • Analysis of contemporary management strategies, including screening, risk stratification, and device implantation.
  • Examination of current clinical guidelines from major cardiology organizations (ACC Foundation/AHA, ESC).

Main Results:

  • Most individuals with HCM can achieve normal or near-normal life expectancy with contemporary management.
  • Guidelines from ACC Foundation/AHA and ESC aid in the evaluation and management of HCM.
  • Advances in genetics, imaging, and molecular research are crucial for future diagnostic and therapeutic progress.

Conclusions:

  • Effective management strategies and guideline adherence are key to improving outcomes for HCM patients.
  • Addressing knowledge gaps and implementation challenges is essential for optimal HCM care.
  • Future research in genetics, imaging, and molecular biology holds promise for enhanced diagnosis and treatment of HCM.

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