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Nutrient sensing, signal transduction and immune responses
Jessica Walls1, Linda Sinclair2, David Finlay3
1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.
Seminars in Immunology
|September 30, 2016
Summary
Immune cells function in nutrient-poor environments, where nutrient availability impacts their signaling and metabolism. Understanding nutrient sensing pathways is crucial for modulating immune responses.
Area of Science:
- Immunology
- Cellular Metabolism
- Nutrient Sensing
Background:
- Immune cells require a constant nutrient supply for metabolism and function.
- Immune cells often operate in nutrient-restricted microenvironments, like tumors and inflammatory sites.
- Low nutrient levels (e.g., glucose, amino acids) can impair immune cell function.
Purpose of the Study:
- To review nutrient sensing signaling pathways in immune cells.
- To discuss the role of nutrients as critical signals in immune responses.
Main Methods:
- Literature review of nutrient sensing pathways.
- Analysis of evidence linking nutrient availability to immune cell function.
Main Results:
- Nutrient sufficiency is vital for immune cell metabolic and biosynthetic pathways.
- Nutrients act as signaling cues influencing immune cell function.
- Specific nutrient levels impact immunological signaling pathways.
Conclusions:
- Nutrient sensing pathways are critical for immune cell function.
- Nutrients significantly shape immune responses by acting as signaling molecules.
Keywords:
Amino acidsCD36CholesterolGCN2GlucoseGlutamineGlycolysisImmunometabolismLCFALXRLymphocyteMacrophageNutrient sensingOxPhosOxysterolsSCFASlc7a5Srebpc-MycmTORC1More Related Videos
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