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Related Experiment Video

Updated: Mar 14, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

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Relation between blood vitamin B12 levels with premature ejaculation: case-control study.

M Kadihasanoglu1, M Kilciler2, G Kilciler3

  • 1Department of Urology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Andrologia
|September 30, 2016
PubMed
Summary
This summary is machine-generated.

Low vitamin B12 levels are linked to premature ejaculation (PE). This study found significantly lower vitamin B12 in men with PE, suggesting a potential correlation and diagnostic marker.

Keywords:
5-hydroxytryptaminepremature ejaculationvitamin B12

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Area of Science:

  • Urology
  • Nutritional Science
  • Men's Health

Background:

  • Premature ejaculation (PE) is a common sexual dysfunction.
  • The potential role of nutritional factors, such as vitamin B12, in PE is not well understood.

Purpose of the Study:

  • To investigate the association between serum vitamin B12 levels and premature ejaculation.
  • To determine if vitamin B12 levels can serve as a biomarker for PE.

Main Methods:

  • A case-control study involving 109 men (56 with PE, 53 controls).
  • Assessment included intravaginal ejaculatory latency time (IELT), Premature Ejaculation Diagnostic Tool (PEDT), International Index of Erectile Function (IIEF), and Beck Depression Inventory (BDI).
  • Serum vitamin B12 levels were measured for all participants.

Main Results:

  • Men with PE had significantly lower mean vitamin B12 levels (213.14 ng/ml) compared to controls (265.89 ng/ml).
  • Lower vitamin B12 levels showed a significant correlation with PE diagnosis via ROC analysis.
  • Vitamin B12 levels correlated significantly with PEDT scores and IELT.

Conclusions:

  • This study demonstrates a significant association between lower vitamin B12 levels and premature ejaculation.
  • Vitamin B12 deficiency may be a contributing factor or a marker for PE.
  • Further research is warranted to explore the therapeutic implications of vitamin B12 supplementation in PE.