Related Experiment Video
Updated: Mar 14, 2026
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
Plasma Catestatin in Patients with Acute Coronary Syndrome
Weixian Xu1, Haiyi Yu, Hubing Wu
1Department of Cardiology, Peking University Third Hospital, Beijing, China.
Insights
Plasma catestatin levels are lower in patients with acute coronary syndrome, including ST-segment elevation myocardial infarction (STEMI) and unstable angina pectoris (UAP), compared to those without coronary artery disease (CAD). No association was found between catestatin levels and long-term cardiovascular events.
Area of Science:
- Cardiology
- Biomarkers
- Clinical Research
Background:
- Acute coronary syndrome (ACS) encompasses conditions like ST-segment elevation myocardial infarction (STEMI) and unstable angina pectoris (UAP).
- Catestatin is a peptide with potential roles in cardiovascular health, but its levels in ACS are not well-established.
Purpose of the Study:
- To quantify plasma catestatin levels in patients diagnosed with ACS.
- To explore the relationship between catestatin levels and long-term major adverse cardiovascular events (MACEs).
Main Methods:
- 170 patients with suspected ACS undergoing coronary angiography were analyzed.
- Patients were categorized into STEMI, UAP, and non-coronary artery disease (CAD) groups.
- A 2-year follow-up assessed MACEs, including cardiovascular death, recurrent myocardial infarction, heart failure, or revascularization.
Main Results:
- Plasma catestatin levels were significantly lower in STEMI and UAP patients compared to the control group without CAD (p=0.001).
- Body mass index, hypertension, and CAD type were independently associated with catestatin levels.
- No significant difference in MACEs was observed between high and low catestatin level groups.
Conclusions:
- Patients with STEMI and UAP exhibit reduced plasma catestatin levels relative to individuals without CAD.
- The study did not find a correlation between plasma catestatin levels and long-term adverse cardiovascular outcomes.
Objectives:
To measure plasma catestatin levels in patients with acute coronary syndrome and investigate whether there is an association between catestatin levels and long-term outcome.
Methods:
Patients (n = 170) with suspected acute coronary syndrome who underwent emergency coronary angiography were enrolled, including 46 with acute ST-segment elevation myocardial infarction (STEMI), 89 with unstable angina pectoris (UAP), and 35 without coronary artery disease (CAD). All patients were followed for 2 years to measure the occurrence of major adverse cardiovascular events (MACEs), including death from a cardiovascular cause, recurrent acute myocardial infarction, or hospital admission for heart failure or revascularization.
Results:
On average, the plasma catestatin levels in patients with STEMI (0.80 ± 0.62 ng/ml) and UAP (0.99 ± 0.63 ng/ml) were significantly lower than the levels seen in the control group with no evidence of CAD (1.38 ± 0.98 ng/ml; p = 0.001). In multivariable linear regression, body mass index, presence of hypertension, and type of CAD were independently related to the plasma catestatin level. However, there were no significant differences in MACEs between patients with high and low levels of catestatin.
Conclusions:
The plasma catestatin levels in patients with STEMI and UAP were lower than the levels seen in patients without CAD.
More Related Videos
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:26Acute Coronary Syndrome V: Nursing Management