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Related Experiment Video

Updated: Mar 14, 2026

Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol
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Internet-based treatment for depression in multiple sclerosis: A randomized controlled trial.

Rosa E Boeschoten1, Joost Dekker2, Bernard Mj Uitdehaag3

  • 1EMGO+ Institute for Mental Health and Care Research/Department of Psychiatry, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|September 30, 2016
PubMed
Summary

Internet-based problem-solving treatment (IPST) did not significantly reduce depressive symptoms in multiple sclerosis (MS) patients compared to a wait list. Unexpected improvements were observed in the control group.

Keywords:
DepressionInternet-based treatmentclinical trialmultiple sclerosisproblem-solving treatment

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Area of Science:

  • Neurology
  • Psychiatry
  • Digital Health

Background:

  • Depression is prevalent in multiple sclerosis (MS) patients, often undertreated due to physical limitations hindering traditional therapy.
  • Internet-based interventions offer a viable solution for delivering mental health support to individuals with MS.

Purpose of the Study:

  • To evaluate the effectiveness of a guided Internet-based problem-solving treatment (IPST) for managing depression in patients with multiple sclerosis.
  • To compare the outcomes of IPST against a wait list control group.

Main Methods:

  • A randomized controlled trial involving 171 MS patients with moderate to severe depressive symptoms.
  • Participants were assigned to either IPST or a wait list control group.
  • Depressive symptoms were assessed using the Beck Depression Inventory Second Edition (BDI-II) at baseline, post-intervention, and 4-month follow-up.

Main Results:

  • Both the IPST and wait list control groups showed significant improvements in depressive symptoms.
  • No statistically significant differences in depression reduction were observed between the IPST group and the wait list control group at post-intervention or 4-month follow-up.
  • A large improvement in depressive symptoms was unexpectedly noted in the wait list control group.

Conclusions:

  • Guided Internet-based problem-solving treatment (IPST) demonstrated no significant advantage over a wait list in reducing depressive symptoms for MS patients.
  • The substantial improvements in the wait list group warrant further investigation and discussion.