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Potential Markers in Cardiac Hypertrophy?

Bartosz Malinowski1, Gabriele Fulgheri2, Michal Wicinski3

  • 1Department of Laboratory Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland; Department of Pharmacology and Therapeutics, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

EJIFCC
|September 30, 2016
PubMed

Insights

Emerging biomarkers like osteopontin and ST-2 receptor show promise for diagnosing cardiomyopathies. This review explores novel biochemical tests to complement traditional methods in cardiology research.

Area of Science:

  • Cardiology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Cardiomyopathies are diagnosed using medical history, physical exams, and imaging like echocardiograms.
  • Current non-invasive diagnostic methods for cardiomyopathies can be enhanced by biochemical tests.

Purpose of the Study:

  • To review emerging potential biomarkers for cardiomyopathy diagnosis.
  • To explore novel biochemical markers that can complement existing diagnostic tools.

Main Methods:

  • Review of human and non-human investigations.
  • Focus on experimental cardiology models, particularly the rat model.

Main Results:

  • Description of emerging biomarkers including osteopontin, ST-2 receptor, osteoprotegerin, neopterin, urocortins, growth differentiation factor 15, and urotensin II.
  • Highlighting the value of animal models in advancing clinical knowledge.

Conclusions:

  • Novel biomarkers offer potential to improve cardiomyopathy diagnosis.
  • Biochemical tests can serve as valuable additions to current diagnostic strategies in cardiology.

Keywords:
CardiomyopathyST-2 receptorbiomarkers of cardiac remodelinggrowth differentiation factor 15heart failureneopterinosteopontinosteoprotegerinurocortinsurotensin II

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