Related Experiment Video
Updated: Mar 14, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Evaluating Biomarkers for Guiding Treatment Decisions.
Patrick M Bossuyt1, Tajik Parvin1
1Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Center, University of Amsterdam , The Netherlands.
Precision medicine uses genetic insights for targeted treatments, moving beyond one-size-fits-all approaches. Biomarkers identify patients who will benefit, ensuring evidence-based, effective medical interventions.
Area of Science:
- Biomedical Science
- Genetics
- Pharmacology
Background:
- The traditional
- blockbuster
- drug strategy is being replaced by precision medicine.
- Genetic advancements enable tailored treatments for individual patients.
- Identifying patients likely to benefit from specific interventions is crucial.
Purpose of the Study:
- To highlight the shift towards precision medicine driven by genetic insights.
- To emphasize the need for evidence-based selection markers in treatment.
- To advocate for quantitative performance evaluation of treatment selection markers.
Main Methods:
- Review of current trends in medical treatment strategies.
- Analysis of the role of biomarkers in patient stratification.
- Discussion on the importance of data-driven research for marker validation.
Main Results:
- Precision medicine offers a more targeted and effective approach to disease treatment.
- Biomarker identification is key to selecting patients for specific therapies.
- The performance of treatment selection markers requires rigorous, quantitative assessment.
Conclusions:
- Genetic revolution facilitates personalized treatment strategies.
- Evidence-based selection markers, validated by sound research, are essential.
- Quantitative evaluation of marker performance ensures treatment efficacy and optimizes patient outcomes.
More Related Videos
07:40Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
Related Concept Videos
Therapeutic Drug Monitoring: Affecting Factors
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Therapeutic Drug Monitoring: Overview and Classification
Therapeutic Drug Monitoring: Drug Analysis Methods