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Updated: Mar 14, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
Published on: January 20, 2022
Soluble ST2 and Galectin-3: What We Know and Don't Know Analytically
Thomas Mueller1, Benjamin Dieplinger1
1Department of Laboratory Medicine, Konventhospital Barmherzige Brueder , Linz, Austria.
Abstract:
The proteins soluble ST2 (sST2) and galectin-3 are currently gaining mounting interest as candidate biomarkers in cardiac disease. Both, sST2 and galectin-3 have been included in the 2013 ACCF/AHA guideline for additive risk stratification of patients with acute and chronic heart failure. The aim of this review is to provide information on analytical considerations of measuring circulating sST2 and galectin-3 including knowledge on in vitro stability, biological variation and reference ranges of both analytes.
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