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Soluble ST2 and Galectin-3: What We Know and Don't Know Analytically
Thomas Mueller1, Benjamin Dieplinger1
1Department of Laboratory Medicine, Konventhospital Barmherzige Brueder , Linz, Austria.
Soluble ST2 (sST2) and galectin-3 show promise as cardiac disease biomarkers. This review details analytical considerations for measuring these proteins, crucial for heart failure risk stratification.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Chemistry
Background:
- Soluble ST2 (sST2) and galectin-3 are emerging biomarkers for cardiac conditions.
- These biomarkers are recognized in heart failure risk stratification guidelines.
Purpose of the Study:
- To review analytical considerations for measuring circulating sST2 and galectin-3.
- To provide insights into in vitro stability, biological variation, and reference ranges.
Main Methods:
- Literature review focusing on analytical methods for sST2 and galectin-3.
- Analysis of data regarding biomarker stability and variability.
Main Results:
- Data on the analytical performance of sST2 and galectin-3 assays are synthesized.
- Information on biological variation and established reference ranges is presented.
Conclusions:
- Accurate measurement of sST2 and galectin-3 requires understanding analytical factors.
- Standardized measurement is essential for reliable clinical application in heart failure management.
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