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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Disorders of the Skeletal Muscle01:28

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Drug Dosing: Obese Patients01:21

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

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Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
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Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Related Experiment Video

Updated: Mar 14, 2026

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
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Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

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TENDINOPATHY AND OBESITY.

Adham do Amaral E Castro1, Thelma Larocca Skare1, Paulo Afonso Nunes Nassif1

  • 1Postgraduate Program in Principles of Surgery, Evangelic Faculty of Paraná/University Evangelic Hospital of Curitiba/Medical Research Institute, Curitiba, PR, Brazil.

Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery
|September 30, 2016
PubMed
Summary
This summary is machine-generated.

Obesity may contribute to tendinopathies and tendon tears through increased mechanical stress and inflammation. Weight loss can improve these musculoskeletal symptoms by reducing inflammatory adipokines.

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Area of Science:

  • Musculoskeletal health
  • Obesity research
  • Inflammation and metabolism

Background:

  • Tendinopathies and tendon tears constitute a significant portion of musculoskeletal consultations.
  • Obesity is a global public health concern with potential links to tendinopathies.

Purpose of the Study:

  • To conduct a literature review on the association between tendinopathies and obesity.

Main Methods:

  • A descriptive, exploratory study design was employed.
  • Literature searches were performed using the Medline database.
  • English-language articles published between 2006 and 2014 were reviewed.

Main Results:

  • Tendinopathy pathogenesis involves simultaneous inflammatory, regenerative, and degenerative processes.
  • Obesity can lead to tendinopathies via tendon overload and increased pro-inflammatory adipokines (adiposopathy).
  • Weight loss is associated with reduced adipokines and improved musculoskeletal symptoms.

Conclusions:

  • Recent evidence supports a link between obesity and tendinopathies.
  • Understanding this association is crucial for managing musculoskeletal conditions in obese populations.